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Thus ozonetherapy can be performed only by physicians after an appropriate training in ozonetherapy using a precise ozone generator equipped with a well-calibrated photometer. On the other hand also ozonetherapy has drawbacks: ozone is a gas intrinsically toxic that cannot be breathed, cannot be stored and must be used with caution and competence. Actually statins produce pleiotropic effects thus resembling ozone because, by inhibiting 3-hydroxyl-3-methylglutaryl coenzyme A reductase, an enzyme crucial to cholesterol and nonsteroidal isoprenoid compounds biosynthesis, they have antiatherosclerotic and surprising immunosuppressive effects (Mach, 2003 Vollmer et al., 2004 McCarey et al., 2004). This example is mentioned not for disregarding conventional medicine but to point out a reality that presents some problems with compliance and eventual outcome. Indeed atherosclerotic patients often complain that during the day they must remember to take six or seven drugs such as a statin, folic acid, antioxidants, an antiaggregant agent, an anticoagulant, an ACE-inhibitor etc., to keep the disease at bay. We know that chronic diseases are the result of a number of dysfunctions and the use of a reductionist approach can be disadvantageous.
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One of the substantial differences between classical pharmacology and ozonetherapy is that this approach generates a heterogeneous number of compounds, which, in submicromolar concentrations, can trigger a variety of functional activities, hence multiple therapeutic responses rarely obtainable with a single drug. 4.3 has tried to give a comprehensive idea of how ozonated blood cells and LOPs interact with a number of organs after the initial reaction of ozone with plasma components.
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In contrast to the dogma that “ozone is always toxic”, three decades of clinical experience, although mostly acquired in private clinics in millions of patients, have shown that ozone can act as a disinfectant, an oxygen donor, an immunomodulator, a paradoxical inducer of antioxidant enzymes, a metabolic enhancer, an inducer of endothelial nitric oxide synthase and possibly an activator of stem cells with consequent neovascularization and tissue reconstruction.įig. The ozone messengers ROS and LOPs can act either locally or systemically in practically all cells of an organism. This seems so because ozone, like oxygen, is a molecule able to act simultaneously on several blood components with different functions but, as we shall discuss, ozonetherapy is not a panacea. The fact that the medical applications are numerous exposes the ozonetherapist to medical derision because superficial observers or sarcastic sceptics consider ozonetherapy as the modern panacea. The reader may be eager to examine in which diseases ozonetherapy can be proficiently used and she/he will be amazed by the versatility of this complementary approach (Table 9.1). In contrast to the dogma that “ozone is always toxic”, three decades of clinical experience, although mostly acquired in private clinics in millions of patients, have shown that ozone can act as a disinfectant, an oxygen donor, an immunomodulator, a paradoxical inducer of antioxidant enzymes, a metabolic enhancer, an inducer of endothelial nitric oxide synthase and possibly an activator of stem cells with consequent neovascularization and tissue reconstruction. The reader may be eager to examine in which diseases ozonetherapy can be proficiently used and she/he will be amazed by the versatility of this complementary approach (Table 9 1).